5OM9

Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with a thiirane mechanism-based inhibitor

Replaces:  4UF4

Summary for 5OM9

• Entry DOI: 10.2210/pdb5om9/pdb
• Descriptor: Carboxypeptidase A1, (2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic acid, ZINC ION, ... (4 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted: P15085
• Total number of polymer chains: 2
• Total formula weight: 94928.83

Authors

Gallego, P.,Granados, C.,Fernandez, D.,Pallares, I.,Covaleda, G.,Aviles, F.X.,Vendrell, J.,Reverter, D. (deposition date: 2017-07-28, release date: 2017-08-09, Last modification date: 2024-01-17)

• Primary citation: Testero, S.A.,Granados, C.,Fernandez, D.,Gallego, P.,Covaleda, G.,Reverter, D.,Vendrell, J.,Aviles, F.X.,Pallares, I.,Mobashery, S.; Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.; ACS Med Chem Lett, 8:1122-1127, 2017; PubMed: 29057062; DOI: 10.1021/acsmedchemlett.7b00346

Experimental method

X-RAY DIFFRACTION (1.8 Å)