4UD9
Thrombin in complex with 5-chlorothiophene-2-carboxamide
Summary for 4UD9
| Entry DOI | 10.2210/pdb4ud9/pdb |
| Related | 4UDH 4UDW 4UE7 |
| Descriptor | Thrombin heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hirudin-2, ... (11 entities in total) |
| Functional Keywords | hydrolase, hydrolase inhibitor complex, serine protease, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, fragment, glycosylation, blood |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 35726.99 |
| Authors | Ruehmann, E.,Heine, A.,Klebe, G. (deposition date: 2014-12-09, release date: 2015-08-26, Last modification date: 2024-01-31) |
| Primary citation | Ruehmann, E.,Betz, M.,Heine, A.,Klebe, G. Fragments Can Bind Either More Enthalpy or Entropy-Driven: Crystal Structures and Residual Hydration Pattern Suggest Why. J.Med.Chem., 58:6960-, 2015 Cited by PubMed: 26270568DOI: 10.1021/ACS.JMEDCHEM.5B00812 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.124 Å) |
Structure validation
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