4U93

Crystal Structure of Hsp90-alpha N-domain Bound to the Inhibitor NVP-HSP990

Summary for 4U93

• Entry DOI: 10.2210/pdb4u93/pdb
• Descriptor: Heat shock protein HSP 90-alpha, (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one (3 entities in total)
• Functional Keywords: atp-binding domain, chaperone
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P07900
• Total number of polymer chains: 1
• Total formula weight: 26981.16

Authors

Bellamacina, C.R.,Shafer, C.M.,Bussiere, D. (deposition date: 2014-08-05, release date: 2014-11-19, Last modification date: 2023-12-27)

• Primary citation: McBride, C.M.,Levine, B.,Xia, Y.,Bellamacina, C.,Machajewski, T.,Gao, Z.,Renhowe, P.,Antonios-McCrea, W.,Barsanti, P.,Brinner, K.,Costales, A.,Doughan, B.,Lin, X.,Louie, A.,McKenna, M.,Mendenhall, K.,Poon, D.,Rico, A.,Wang, M.,Williams, T.E.,Abrams, T.,Fong, S.,Hendrickson, T.,Lei, D.,Lin, J.,Menezes, D.,Pryer, N.,Taverna, P.,Xu, Y.,Zhou, Y.,Shafer, C.M.; Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990.; J.Med.Chem., 57:9124-9129, 2014; PubMed: 25368984; DOI: 10.1021/jm501107q

Experimental method

X-RAY DIFFRACTION (1.55 Å)