4TW9
Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1delta and epsilon with nanomolar inhibitory activity on cancer cell proliferation
Summary for 4TW9
Entry DOI | 10.2210/pdb4tw9/pdb |
Descriptor | Casein kinase I isoform delta, SULFATE ION, octyl beta-L-talopyranoside, ... (7 entities in total) |
Functional Keywords | transferase, ck1delta, ck1epsilon, phosphorylation, small molecule inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 71192.10 |
Authors | Richter, J.,Bischof, J.,Zaja, M.,Kohlhof, H.,Othersen, O.,Vitt, D.,Alscher, V.,Pospiech, I.,Garcia-Reyes, B.,Berg, S.,Leban, J.,Knippschild, U. (deposition date: 2014-06-30, release date: 2014-07-30, Last modification date: 2024-05-08) |
Primary citation | Richter, J.,Bischof, J.,Zaja, M.,Kohlhof, H.,Othersen, O.,Vitt, D.,Alscher, V.,Pospiech, I.,Garcia-Reyes, B.,Berg, S.,Leban, J.,Knippschild, U. Difluoro-dioxolo-benzoimidazol-benzamides As Potent Inhibitors of CK1 delta and epsilon with Nanomolar Inhibitory Activity on Cancer Cell Proliferation. J.Med.Chem., 57:7933-7946, 2014 Cited by PubMed: 25191940DOI: 10.1021/jm500600b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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