4RX2
A triple mutant in the omega-loop of TEM-1 beta-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis
Summary for 4RX2
Entry DOI | 10.2210/pdb4rx2/pdb |
Related | 4RVA |
Descriptor | Beta-lactamase TEM, SULFATE ION (3 entities in total) |
Functional Keywords | globular, beta-lactamase, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 8 |
Total formula weight | 231831.42 |
Authors | Stojanoski, V.,Chow, D.,Hu, L.,Sankaran, B.,Gilbert, H.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2014-12-08, release date: 2015-03-04, Last modification date: 2023-09-20) |
Primary citation | Stojanoski, V.,Chow, D.C.,Hu, L.,Sankaran, B.,Gilbert, H.F.,Prasad, B.V.,Palzkill, T. A Triple Mutant in the Omega-loop of TEM-1 beta-Lactamase Changes the Substrate Profile via a Large Conformational Change and an Altered General Base for Catalysis. J.Biol.Chem., 290:10382-10394, 2015 Cited by PubMed: 25713062DOI: 10.1074/jbc.M114.633438 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.315 Å) |
Structure validation
Download full validation report