4RV8
Co-Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Cryptosporidium parvum and the inhibitor p131
Summary for 4RV8
Entry DOI | 10.2210/pdb4rv8/pdb |
Related | 3FFS 4IXH |
Descriptor | Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, 1-(2-{3-[(1E)-N-(2-aminoethoxy)ethanimidoyl]phenyl}propan-2-yl)-3-(4-chloro-3-nitrophenyl)urea, ... (6 entities in total) |
Functional Keywords | structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, alpha-beta fold, tim barrel, oxidoreductase |
Biological source | Cryptosporidium parvum More |
Cellular location | Cytoplasm : Q8T6T2 |
Total number of polymer chains | 4 |
Total formula weight | 157926.68 |
Authors | Kim, Y.,Makowska-Grzyska, M.,Gu, M.,Kavitha, M.,Hedstrom, L.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2014-11-25, release date: 2014-12-31, Last modification date: 2023-12-06) |
Primary citation | Kim, Y.,Makowska-Grzyska, M.,Gorla, S.K.,Gollapalli, D.R.,Cuny, G.D.,Joachimiak, A.,Hedstrom, L. Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallogr F Struct Biol Commun, 71:531-538, 2015 Cited by PubMed: 25945705DOI: 10.1107/S2053230X15000187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.053 Å) |
Structure validation
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