4RU9

Crystal structure of human DNA polymerase eta inserting dCMPNPP opposite a MeFapy-dG adducted DNA template

Summary for 4RU9

• Entry DOI: 10.2210/pdb4ru9/pdb
• Related: 4RUA
• Descriptor: DNA polymerase eta, Nucleic acids Template: CAT(MF7)ATGACGCT, Nucleic acids Primar: AGCGTCAT, ... (6 entities in total)
• Functional Keywords: dna damage, dna-directed dna polymerase, cytidine triphosphate, y-family polymerase, trans-lesion synthesis (tls), dna binding, mefapy-dg lesion bypass, 2, 6-diamino-4-hydroxy-n(5)-(methyl)-formamidopyrimidine (mefapy-dg) lesion, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : Q9Y253
• Total number of polymer chains: 3
• Total formula weight: 54961.24

Authors

Patra, A.,Egli, M. (deposition date: 2014-11-18, release date: 2015-08-05, Last modification date: 2023-09-20)

• Primary citation: Patra, A.,Banerjee, S.,Johnson Salyard, T.L.,Malik, C.K.,Christov, P.P.,Rizzo, C.J.,Stone, M.P.,Egli, M.; Structural Basis for Error-Free Bypass of the 5-N-Methylformamidopyrimidine-dG Lesion by Human DNA Polymerase eta and Sulfolobus solfataricus P2 Polymerase IV.; J.Am.Chem.Soc., 137:7011-7014, 2015; PubMed: 25988947; DOI: 10.1021/jacs.5b02701

Experimental method

X-RAY DIFFRACTION (2.65 Å)