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4RFW

Crystal structure of human retinoid X Receptor alpha-ligand binding domain complex with 9cUAB70 and the coactivator peptide GRIP-1

Summary for 4RFW
Entry DOI10.2210/pdb4rfw/pdb
Related3OAP 4K4J
DescriptorRetinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-3,7-dimethyl-8-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylidene)octa-2,4,6-trienoic acid, ... (4 entities in total)
Functional Keywordsligand binding domain, cancer prevention, coactivator peptide, conformationally constrained retinoids, transcription
Biological sourceHomo sapiens (human)
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Cellular locationNucleus : P19793 Q15596
Total number of polymer chains2
Total formula weight27785.30
Authors
Xia, G.,Muccio, D.D.,Smith, C.D. (deposition date: 2014-09-28, release date: 2015-09-16, Last modification date: 2023-09-20)
Primary citationAtigadda, V.R.,Xia, G.,Deshpande, A.,Wu, L.,Kedishvili, N.,Smith, C.D.,Krontiras, H.,Bland, K.I.,Grubbs, C.J.,Brouillette, W.J.,Muccio, D.D.
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
J.Med.Chem., 58:7763-7774, 2015
Cited by
PubMed: 26331194
DOI: 10.1021/acs.jmedchem.5b00829
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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