4RDA
X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE
Summary for 4RDA
Entry DOI | 10.2210/pdb4rda/pdb |
Related | 4RD9 |
Descriptor | Amyloid-like protein 1, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, ... (5 entities in total) |
Functional Keywords | heparan sulfate binding, sugar binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. C30: Cytoplasm: P51693 |
Total number of polymer chains | 2 |
Total formula weight | 52148.05 |
Authors | Dahms, S.O.,Than, M.E. (deposition date: 2014-09-18, release date: 2015-03-11, Last modification date: 2024-02-28) |
Primary citation | Dahms, S.O.,Mayer, M.C.,Roeser, D.,Multhaup, G.,Than, M.E. Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes. Acta Crystallogr.,Sect.D, 71:494-504, 2015 Cited by PubMed: 25760599DOI: 10.1107/S1399004714027114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.497 Å) |
Structure validation
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