4RDA
X-RAY STRUCTURE OF THE AMYLOID PRECURSOR PROTEIN-LIKE PROTEIN 1 (APLP1) E2 DOMAIN IN COMPLEX WITH A HEPARIN DODECASACCHARIDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Amyloid-like protein 1 | polymer | 210 | 24460.5 | 2 | UniProt (P51693) Pfam (PF12925) | Homo sapiens (human) | APLP, APLP-1, C30 |
| 2 | C (C) | 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid | branched | 1411.1 | 1 | In PDB GlyTouCan (G25610IB) | |||
| 3 | D (D) | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid | branched | 1750.4 | 1 | In PDB GlyTouCan (G82873VJ) | |||
| 4 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 68 | Chemie (HOH) |
Sequence modifications
A, B: 290 - 495 (UniProt: P51693)
| PDB | External Database | Details |
|---|---|---|
| Glu 286 | - | cloning artifact |
| Ala 287 | - | cloning artifact |
| Glu 288 | - | cloning artifact |
| Phe 289 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48921.1 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3161.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 52148.1 |
