4RAV

Crystal structure of scFvC4 in complex with the first 17 AA of huntingtin

Summary for 4RAV

• Entry DOI: 10.2210/pdb4rav/pdb
• Descriptor: Single-chain Fv, VL, single-chain Fv, VH, Huntingtin, ... (5 entities in total)
• Functional Keywords: immunoglobulin fold, immunity, 1-17 residues of huntingtin, immune system-apoptosis complex, immune system/apoptosis
• Biological source: Homo sapiens; More
• Cellular location: Cytoplasm: P42858
• Total number of polymer chains: 6
• Total formula weight: 55677.19

Authors

De Genst, E.,Chirgadze, D.Y.,Dobson, C.M. (deposition date: 2014-09-11, release date: 2015-07-29)

• Primary citation: De Genst, E.,Chirgadze, D.Y.,Klein, F.A.,Butler, D.C.,Matak-Vinkovic, D.,Trottier, Y.,Huston, J.S.,Messer, A.,Dobson, C.M.; Structure of a single-chain fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.; J.Mol.Biol., 427:2166-2178, 2015; PubMed: 25861763; DOI: 10.1016/j.jmb.2015.03.021

Experimental method

X-RAY DIFFRACTION (2.5 Å)