4R7H
Crystal structure of FMS KINASE domain with a small molecular inhibitor, PLX3397
Summary for 4R7H
Entry DOI | 10.2210/pdb4r7h/pdb |
Descriptor | Macrophage colony-stimulating factor 1 receptor, 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-N-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine (3 entities in total) |
Functional Keywords | csf-1-r, fms proto-oncogene, c-fms, cd115 antigen, kinase, atp-binding, plx3397, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P07333 |
Total number of polymer chains | 1 |
Total formula weight | 39057.99 |
Authors | |
Primary citation | Tap, W.D.,Wainberg, Z.A.,Anthony, S.P.,Ibrahim, P.N.,Zhang, C.,Healey, J.H.,Chmielowski, B.,Staddon, A.P.,Cohn, A.L.,Shapiro, G.I.,Keedy, V.L.,Singh, A.S.,Puzanov, I.,Kwak, E.L.,Wagner, A.J.,Von Hoff, D.D.,Weiss, G.J.,Ramanathan, R.K.,Zhang, J.,Habets, G.,Zhang, Y.,Burton, E.A.,Visor, G.,Sanftner, L.,Severson, P.,Nguyen, H.,Kim, M.J.,Marimuthu, A.,Tsang, G.,Shellooe, R.,Gee, C.,West, B.L.,Hirth, P.,Nolop, K.,van de Rijn, M.,Hsu, H.H.,Peterfy, C.,Lin, P.S.,Tong-Starksen, S.,Bollag, G. Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor. N Engl J Med, 373:428-437, 2015 Cited by PubMed: 26222558DOI: 10.1056/NEJMoa1411366 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8001 Å) |
Structure validation
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