4R3C
Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate
Summary for 4R3C
Entry DOI | 10.2210/pdb4r3c/pdb |
Related | 4EWQ 4F9W 4F9Y |
Descriptor | Mitogen-activated protein kinase 14, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine, ... (5 entities in total) |
Functional Keywords | serine/threonine-protein kinase, protein kinase domain, transferase, atp binding, phosphorylation, cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 45069.67 |
Authors | Grum-Tokars, V.L.,Minasov, G.,Roy, S.M.,Anderson, W.F.,Watterson, D.M. (deposition date: 2014-08-14, release date: 2015-02-25, Last modification date: 2017-11-22) |
Primary citation | Roy, S.M.,Grum-Tokars, V.L.,Schavocky, J.P.,Saeed, F.,Staniszewski, A.,Teich, A.F.,Arancio, O.,Bachstetter, A.D.,Webster, S.J.,Van Eldik, L.J.,Minasov, G.,Anderson, W.F.,Pelletier, J.C.,Watterson, D.M. Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models. ACS Chem Neurosci, 6:666-680, 2015 Cited by PubMed: 25676389DOI: 10.1021/acschemneuro.5b00002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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