4R1E

Crystal Structure of MTIP from Plasmodium falciparum in complex with a peptide-fragment chimera

Summary for 4R1E

Entry DOI	10.2210/pdb4r1e/pdb
Related	4AOM 4MZJ 4MZK 4MZL
Descriptor	Myosin A tail domain interacting protein, Myosin-A, 5-{[(2-aminoethyl)sulfanyl]methyl}furan-2-carbaldehyde, ... (4 entities in total)
Functional Keywords	calmodulin-like, protein binding, myosin motor, fragment peptide, membrane, protein binding-inhibitor complex, protein binding/inhibitor
Biological source	Plasmodium falciparum More
Cellular location	Cell membrane ; Peripheral membrane protein ; Cytoplasmic side : Q8IDR3
Total number of polymer chains	2
Total formula weight	18424.65
Authors	Douse, C.H.,Vrielink, N.,Cota, E.,Tate, E.W. (deposition date: 2014-08-05, release date: 2014-11-12, Last modification date: 2023-09-20)
Primary citation	Douse, C.H.,Vrielink, N.,Wenlin, Z.,Cota, E.,Tate, E.W. Targeting a Dynamic Protein-Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex. Chemmedchem, 10:134-143, 2015 Cited by PubMed: 25367834 DOI: 10.1002/cmdc.201402357 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation