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4QLF

Crystal structure of I14G DHFR mutant complexed with folate and NADP+

Summary for 4QLF
Entry DOI10.2210/pdb4qlf/pdb
Related4QLE 4QLG
DescriptorDihydrofolate reductase, FOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
Functional Keywordsdihydrofolate-reductase like fold/alpha and beta proteins (a/b), oxidoreductase activity, nadp(h) binding, oxidoreductase
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight19148.04
Authors
Stojkovic, V.,Gakhar, L.,Kohen, A. (deposition date: 2014-06-12, release date: 2014-11-26, Last modification date: 2023-09-20)
Primary citationDoron, D.,Stojkovic, V.,Gakhar, L.,Vardi-Kilshtain, A.,Kohen, A.,Major, D.T.
Free energy simulations of active-site mutants of dihydrofolate reductase.
J.Phys.Chem.B, 119:906-916, 2015
Cited by
PubMed: 25382260
DOI: 10.1021/jp5059963
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.44 Å)
Structure validation

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