4QLF

Crystal structure of I14G DHFR mutant complexed with folate and NADP+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004146	molecular_function	dihydrofolate reductase activity
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE FOL A 201

Chain	Residue
A	ILE5
A	ARG57
A	ILE94
A	TYR100
A	THR113
A	HOH302
A	HOH355
A	HOH376
A	ALA6
A	ALA7
A	ASP27
A	LEU28
A	ALA29
A	PHE31
A	LYS32
A	ILE50

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site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAP A 202

Chain	Residue
A	GLY43
A	ARG44
A	HIS45
A	THR46
A	LEU62
A	SER63
A	SER64
A	LYS76
A	ASP79
A	GLY96
A	GLY97
A	ARG98
A	VAL99
A	GLN102
A	HIS124
A	HOH324
A	HOH328
A	HOH334
A	HOH429
A	HOH455

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