4Q3H

The crystal structure of NHERF1 PDZ2 CXCR2 complex revealed by the NHERF1 CXCR2 chimeric protein

Summary for 4Q3H

Entry DOI	10.2210/pdb4q3h/pdb
Descriptor	Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (2 entities in total)
Functional Keywords	scaffold protein, dimerization, neutrophil chemotaxis, immune system
Biological source	Homo sapiens (human) More
Cellular location	Cell membrane; Multi-pass membrane protein: P25025
Total number of polymer chains	2
Total formula weight	19832.47
Authors	Holcomb, J.,Jiang, Y.,Trescott, L.,Lu, G.,Brunzelle, J.,Sirinupong, N.,Li, C.,Yang, Z. (deposition date: 2014-04-11, release date: 2014-05-21, Last modification date: 2024-02-28)
Primary citation	Holcomb, J.,Jiang, Y.,Guan, X.,Trescott, L.,Lu, G.,Hou, Y.,Wang, S.,Brunzelle, J.,Sirinupong, N.,Li, C.,Yang, Z. Crystal structure of the NHERF1 PDZ2 domain in complex with the chemokine receptor CXCR2 reveals probable modes of PDZ2 dimerization. Biochem.Biophys.Res.Commun., 448:169-174, 2014 Cited by PubMed: 24768637 DOI: 10.1016/j.bbrc.2014.04.085 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.443 Å)

Structure validation