Crystal structure of the active G-protein-coupled receptor opsin in complex with the finger-loop peptide derived from the full-length arrestin-1

Summary for 4PXF
Related PRD IDPRD_900006
DescriptorRhodopsin, S-arrestin, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywordsretinal protein, photoreceptor, g-protein coupled receptor, phosphoprotein, photoreceptor protein, sensory transduction, transducer, transmembrane, vision, signaling protein, visual arrestin, desensitisation of the visual transduction cascade, binding to acticated and phosphorylated rhodopsin, rhodopsin, opsin
Biological sourceBos taurus (Bovine)
Cellular locationMembrane; Multi-pass membrane protein: P02699
Total number of polymer chains2
Total formula weight42650.43
Szczepek, M.,Scheerer, P. (deposition date: 2014-03-23, release date: 2014-09-17, Last modification date: 2020-07-29)
Primary citationBartl, F.J.,Beyriere, F.,Elgeti, M.,Heck, M.,Hildebrand, P.W.,Hofmann, K.P.,Kazmin, R.,Rose, A.,Scheerer, P.,Sommer, M.E.,Szczepek, M.,von Stetten, D.
Crystal structure of a common GPCR-binding interface for G protein and arrestin.
Nat Commun, 5:4801-4801, 2014
PubMed: 25205354
DOI: 110.1038/ncomms5801
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-23