4PME
Human transthyretin (TTR) complexed with ferulic acid and curcumin.
Summary for 4PME
| Entry DOI | 10.2210/pdb4pme/pdb |
| Related | 4PM1 4PMF |
| Descriptor | Transthyretin, (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, SODIUM ION, ... (6 entities in total) |
| Functional Keywords | human transthyretin (ttr) complexes, solubilization of hydrophobic ligands, curcumin degradation, thyroid hormone-binding protein |
| Biological source | Homo sapiens (Human) |
| Cellular location | Secreted: P02766 |
| Total number of polymer chains | 2 |
| Total formula weight | 26764.96 |
| Authors | Stura, E.A.,Ciccone, L. (deposition date: 2014-05-21, release date: 2014-10-08, Last modification date: 2023-09-27) |
| Primary citation | Ciccone, L.,Tepshi, L.,Nencetti, S.,Stura, E.A. Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32:54-64, 2014 Cited by PubMed: 25224922DOI: 10.1016/j.nbt.2014.09.002 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.264 Å) |
Structure validation
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