4PLB
Crystal Structure of S.A. gyrase-AM8191 complex
Summary for 4PLB
Entry DOI | 10.2210/pdb4plb/pdb |
Descriptor | DNA (5'-D(P*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), Chimera protein of DNA gyrase subunits B and A, 6-[({(1r,4S)-1-[(1S)-2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl]-2-oxabicyclo[2.2.2]oct-4-yl}amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, ... (6 entities in total) |
Functional Keywords | gyase inhibitor complex, isomerase-isomerase inhibitor-dna complex, isomerase/isomerase inhibitor/dna |
Biological source | Staphylococcus aureus More |
Cellular location | Cytoplasm : P20831 |
Total number of polymer chains | 4 |
Total formula weight | 169329.35 |
Authors | Lu, J.,Patel, S.,Soisson, S. (deposition date: 2014-05-16, release date: 2014-06-18, Last modification date: 2023-12-27) |
Primary citation | Singh, S.B.,Kaelin, D.E.,Wu, J.,Miesel, L.,Tan, C.M.,Meinke, P.T.,Olsen, D.,Lagrutta, A.,Bradley, P.,Lu, J.,Patel, S.,Rickert, K.W.,Smith, R.F.,Soisson, S.,Wei, C.,Fukuda, H.,Kishii, R.,Takei, M.,Fukuda, Y. Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents. Acs Med.Chem.Lett., 5:609-614, 2014 Cited by PubMed: 24900889DOI: 10.1021/ml500069w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
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