4PIY

Homocysteine bound Cysteine Dioxygenase C93A variant at pH 6.2

Summary for 4PIY

Entry DOI	10.2210/pdb4piy/pdb
Related	4IEO 4IEP 4IEQ 4IER 4IES 4IET 4IEU 4IEV 4IEW 4IEX 4IEY 4IEZ 4JTN 4JTO
Descriptor	Cysteine dioxygenase type 1, FE (III) ION, 2-AMINO-4-MERCAPTO-BUTYRIC ACID, ... (4 entities in total)
Functional Keywords	cupin fold, catalyzes oxidation, cysteine to cysteine sulfinate, c93-y157 crosslink, cytosol, oxidoreductase
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	1
Total formula weight	23217.85
Authors	Driggers, C.M.,Karplus, P.A. (deposition date: 2014-05-09, release date: 2016-02-17, Last modification date: 2024-04-03)
Primary citation	Driggers, C.M.,Kean, K.M.,Hirschberger, L.L.,Cooley, R.B.,Stipanuk, M.H.,Karplus, P.A. Structure-Based Insights into the Role of the Cys-Tyr Crosslink and Inhibitor Recognition by Mammalian Cysteine Dioxygenase. J. Mol. Biol., 428:3999-4012, 2016 Cited by PubMed: 27477048 DOI: 10.1016/j.jmb.2016.07.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation