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4P7M

Crystal structure of Plasmodium falciparum MIF in complex with 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol

Summary for 4P7M
Entry DOI10.2210/pdb4p7m/pdb
Related4P7S
DescriptorMacrophage migration inhibitory factor-like protein, 3-[(2-methyl-6-phenylpyridin-4-yl)oxy]phenol (2 entities in total)
Functional Keywordsmalaria, inhibitor, active site, complex, cytokine-inhibitor complex, cytokine/inhibitor
Biological sourcePlasmodium falciparum
Total number of polymer chains3
Total formula weight38275.98
Authors
Pantouris, G.,Lolis, E. (deposition date: 2014-03-27, release date: 2014-10-15, Last modification date: 2023-12-27)
Primary citationPantouris, G.,Rajasekaran, D.,Garcia, A.B.,Ruiz, V.G.,Leng, L.,Jorgensen, W.L.,Bucala, R.,Lolis, E.J.
Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors.
J.Med.Chem., 57:8652-8656, 2014
Cited by
PubMed Abstract: We report the crystal structures of two inhibitors of Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) with nanomolar Ki's, analyze their interactions with the active site of PfMIF, and provide explanations regarding their selectivity of PfMIF versus human MIF. These inhibitors were also found to selectively inhibit interactions between PfMIF and the human MIF receptor CD74. The results of this study provide the framework for the development of new therapeutics that target PfMIF.
PubMed: 25268646
DOI: 10.1021/jm501168q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.02 Å)
Structure validation

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