4P58

Crystal structure of mouse comt bound to an inhibitor

Summary for 4P58

Entry DOI	10.2210/pdb4p58/pdb
Descriptor	Catechol O-methyltransferase, 1',3'-dimethyl-1H,1'H-3,4'-bipyrazole (3 entities in total)
Functional Keywords	sam binding site, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mus musculus (Mouse)
Cellular location	Isoform Soluble: Cytoplasm. Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side: O88587
Total number of polymer chains	1
Total formula weight	23996.55
Authors	Lanier, M. (deposition date: 2014-03-15, release date: 2014-06-25, Last modification date: 2023-09-27)
Primary citation	Lanier, M.,Ambrus, G.,Cole, D.C.,Davenport, R.,Ellery, J.,Fosbeary, R.,Jennings, A.J.,Kadotani, A.,Kamada, Y.,Kamran, R.,Matsumoto, S.,Mizukami, A.,Okubo, S.,Okada, K.,Saikatendu, K.,Walsh, L.,Wu, H.,Hixon, M.S. A fragment-based approach to identifying S-adenosyl-l-methionine -competitive inhibitors of catechol O-methyl transferase (COMT). J.Med.Chem., 57:5459-5463, 2014 Cited by PubMed: 24847974 DOI: 10.1021/jm500475k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.06 Å)

Structure validation