4OQ5
Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid
Summary for 4OQ5
Entry DOI | 10.2210/pdb4oq5/pdb |
Related | 4OQ6 |
Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1, 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid (3 entities in total) |
Functional Keywords | apoptosis-inhibitor complex, apoptosis/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass membrane protein (Potential): Q07820 |
Total number of polymer chains | 6 |
Total formula weight | 114100.31 |
Authors | Petros, A.M.,Swann, S.L.,Song, D.,Swinger, K.,Park, C.,Zhang, H.,Wendt, M.D.,Kunzer, A.R.,Souers, A.J.,Sun, C. (deposition date: 2014-02-07, release date: 2014-03-12, Last modification date: 2024-02-28) |
Primary citation | Petros, A.M.,Swann, S.L.,Song, D.,Swinger, K.,Park, C.,Zhang, H.,Wendt, M.D.,Kunzer, A.R.,Souers, A.J.,Sun, C. Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein. Bioorg.Med.Chem.Lett., 24:1484-1488, 2014 Cited by PubMed: 24582986DOI: 10.1016/j.bmcl.2014.02.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.86 Å) |
Structure validation
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