4OQ5
Crystal Structure of Human MCL-1 Bound to Inhibitor 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 163 | 18507.1 | 6 | UniProt (Q07820) Pfam (PF00452) | Homo sapiens (human) | Bcl-2-like protein 3, Bcl2-L-3, Bcl-2-related protein EAT/mcl1, mcl1/EAT |
| 2 | G, H, I, J, K... (A, B, C, D, E...) | 4-(4-methylnaphthalen-1-yl)-2-{[(4-phenoxyphenyl)sulfonyl]amino}benzoic acid | non-polymer | 509.6 | 6 | Chemie (2UU) | |||
| 3 | M, N, O, P, Q... (A, B, C, D, E...) | water | water | 18.0 | 154 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 174 - 326 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly 164 | - | expression tag |
| Thr 165 | - | expression tag |
| Leu 166 | - | expression tag |
| Val 167 | - | expression tag |
| Pro 168 | - | expression tag |
| Arg 169 | - | expression tag |
| Gly 170 | - | expression tag |
| Ser 171 | - | expression tag |
| Met 172 | - | expression tag |
| Asp 173 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 111042.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3057.4 | |
| All* | Total formula weight | 114100.3 |
