4OI7

RAGE recognizes nucleic acids and promotes inflammatory responses to DNA

Replaces:  3S58

Summary for 4OI7

• Entry DOI: 10.2210/pdb4oi7/pdb
• Related: 4OI8
• Descriptor: Advanced glycosylation end product-specific receptor, 5'-D(*CP*TP*GP*CP*AP*AP*CP*GP*AP*TP*GP*CP*TP*AP*CP*GP*AP*AP*CP*GP*TP*G)-3', 5'-D(*CP*AP*CP*GP*TP*TP*CP*GP*TP*AP*GP*CP*AP*TP*CP*GP*TP*TP*GP*CP*AP*G)-3', ... (5 entities in total)
• Functional Keywords: protein-dna complex, ig fold, dna binding, extracellular receptor, transport protein, signaling protein-dna complex, signaling protein/dna
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: Q15109
• Total number of polymer chains: 4
• Total formula weight: 62144.16

Authors

Jin, T.,Jiang, J.,Xiao, T. (deposition date: 2014-01-19, release date: 2014-04-30, Last modification date: 2023-09-20)

• Primary citation: Sirois, C.M.,Jin, T.,Miller, A.L.,Bertheloot, D.,Nakamura, H.,Horvath, G.L.,Mian, A.,Jiang, J.,Schrum, J.,Bossaller, L.,Pelka, K.,Garbi, N.,Brewah, Y.,Tian, J.,Chang, C.,Chowdhury, P.S.,Sims, G.P.,Kolbeck, R.,Coyle, A.J.,Humbles, A.A.,Xiao, T.S.,Latz, E.; RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.; J.Exp.Med., 210:2447-2463, 2013; PubMed: 24081950; DOI: 10.1084/jem.20120201

Experimental method

X-RAY DIFFRACTION (3.104 Å)