4OD9
Structure of Cathepsin D with inhibitor N-(3,4-dimethoxybenzyl)-Nalpha-{N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl}-D-phenylalaninamide
Summary for 4OD9
Entry DOI | 10.2210/pdb4od9/pdb |
Related | 1LYA 4OBZ 4OC6 |
Descriptor | Cathepsin D light chain, Cathepsin D heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | lysosomal aspartic protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 77885.55 |
Authors | Graedler, U.,Czodrowski, P.,Tsaklakidis, C.,Klein, M.,Maskos, K.,Leuthner, B. (deposition date: 2014-01-10, release date: 2014-08-13, Last modification date: 2020-07-29) |
Primary citation | Gradler, U.,Czodrowski, P.,Tsaklakidis, C.,Klein, M.,Werkmann, D.,Lindemann, S.,Maskos, K.,Leuthner, B. Structure-based optimization of non-peptidic Cathepsin D inhibitors. Bioorg.Med.Chem.Lett., 24:4141-4150, 2014 Cited by PubMed: 25086681DOI: 10.1016/j.bmcl.2014.07.054 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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