4OD9

Structure of Cathepsin D with inhibitor N-(3,4-dimethoxybenzyl)-Nalpha-{N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl}-D-phenylalaninamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Cathepsin D light chain	polymer	103	11273.6	2	UniProt (P07339)	Homo sapiens (human)
2	B, D (B, D)	Cathepsin D heavy chain	polymer	243	26540.6	2	UniProt (P07339) Pfam (PF00026)	Homo sapiens (human)
3	E, F (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	G, K (A, D)	N-(3,4-dimethoxybenzyl)-Nalpha-{N-[(3,4-dimethoxyphenyl)acetyl]carbamimidoyl}-D-phenylalaninamide	non-polymer		534.6	2	Chemie (2RZ)
5	H (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
6	I, J (B, D)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
7	L, M, N, O (A, B, C, D)	water	water		18.0	500	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	75628.2
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	5
	Total formula weight	1408.5
All*	Total formula weight	77885.5

*Water molecules are not included.