4OD2

Crystal structure of the Fab fragment of an anti-DR5 antibody bound to DR5

Summary for 4OD2

• Entry DOI: 10.2210/pdb4od2/pdb
• Related: 1d0g
• Descriptor: Fab fragment of drozitumab, light chain, Fab fragment of drozitumab, heavy chain, Tumor necrosis factor receptor superfamily member 10B (3 entities in total)
• Functional Keywords: igg, fab fragment, crd, tnfsf, apoptosis-immune system complex, apoptosis/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: O14763
• Total number of polymer chains: 3
• Total formula weight: 59358.91

Authors

Hymowitz, S.G.,Compaan, D. (deposition date: 2014-01-09, release date: 2014-02-05, Last modification date: 2023-09-20)

• Primary citation: Adams, C.,Totpal, K.,Lawrence, D.,Marsters, S.,Pitti, R.,Yee, S.,Ross, S.,Deforge, L.,Koeppen, H.,Sagolla, M.,Compaan, D.,Lowman, H.,Hymowitz, S.,Ashkenazi, A.; Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5.; Cell Death Differ., 15:751-761, 2008; PubMed: 18219321; DOI: 10.1038/sj.cdd.4402306

Experimental method

X-RAY DIFFRACTION (3.2 Å)