4O2P

Kinase domain of cSrc in complex with a substituted pyrazolopyrimidine

Summary for 4O2P

Entry DOI	10.2210/pdb4o2p/pdb
Descriptor	Proto-oncogene tyrosine-protein kinase Src, 1-[(2R)-2-chloro-2-phenylethyl]-6-{[2-(morpholin-4-yl)ethyl]sulfanyl}-N-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
Functional Keywords	pyrazolo-pyrimidine ligand, type i, dfg-in, tyrosine protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Gallus gallus (bantam,chickens)
Cellular location	Cell membrane : P00523
Total number of polymer chains	2
Total formula weight	66443.37
Authors	Richters, A.,Rauh, D. (deposition date: 2013-12-17, release date: 2015-03-04, Last modification date: 2023-09-20)
Primary citation	Tintori, C.,Fallacara, A.L.,Radi, M.,Zamperini, C.,Dreassi, E.,Crespan, E.,Maga, G.,Schenone, S.,Musumeci, F.,Brullo, C.,Richters, A.,Gasparrini, F.,Angelucci, A.,Festuccia, C.,Delle Monache, S.,Rauh, D.,Botta, M. Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. J.Med.Chem., 58:347-361, 2015 Cited by PubMed: 25469771 DOI: 10.1021/jm5013159 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation