4NLN

Structure of human DNA polymerase beta complexed with nicked DNA containing a template 8BrG and incoming CTP

Summary for 4NLN

• Entry DOI: 10.2210/pdb4nln/pdb
• Related: 1BPX 3ISB 4NLK 4NLZ 4NM1 4NM2
• Descriptor: DNA polymerase beta, 5'-D(*CP*CP*GP*AP*CP*(BGM)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*AP*C)-3', ... (8 entities in total)
• Functional Keywords: dna binding, helix-turn-helix motif, polymerase fold, nucleotidyl transferase, nucleus, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P06746
• Total number of polymer chains: 4
• Total formula weight: 47559.62

Authors

Koag, M.-C.,Min, K.,Monzingo, A.F.,Lee, S. (deposition date: 2013-11-14, release date: 2014-01-22, Last modification date: 2024-02-28)

• Primary citation: Koag, M.C.,Min, K.,Lee, S.; Structural basis for promutagenicity of 8-halogenated Guanine.; J.Biol.Chem., 289:6289-6298, 2014; PubMed: 24425881; DOI: 10.1074/jbc.M113.537803

Experimental method

X-RAY DIFFRACTION (2.261 Å)