4NIB

Crystal structure of human insulin mutant B20 D-ala, B23 D-ala

Summary for 4NIB
DescriptorInsulin A chain, Insulin B chain (3 entities in total)
Functional Keywordshormone
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5845.70
Authors
Menting, J.G.,Lawrence, M.C. (deposition date: 2013-11-05, release date: 2014-08-27, Last modification date: 2015-05-06)
Primary citationCarroll, J.M.,Chan, S.J.,Chauhan, V.S.,Ismail-Beigi, F.,Lawrence, M.C.,Menting, J.G.,Milewski, W.,Pandyarajan, V.,Phillips, N.B.,Roberts, C.T.,Smith, B.J.,Steiner, D.F.,Strokes, N.,Wan, Z.L.,Ward, C.W.,Weiss, M.A.,Whittaker, J.,Whittaker, L.J.,Wickramasinghe, N.P.,Yadav, S.P.,Yang, Y.
Protective hinge in insulin opens to enable its receptor engagement.
Proc.Natl.Acad.Sci.USA, 111:E3395-E3404, 2014
PubMed: 25092300
DOI: 110.1073/pnas.1412897111
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation
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PDB entries from 2021-06-23