4NI1

Quaternary R CO-liganded hemoglobin structure in complex with a thiol containing compound

Summary for 4NI1

• Entry DOI: 10.2210/pdb4ni1/pdb
• Related: 4NI0
• Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (7 entities in total)
• Functional Keywords: allosteric, tetramer, oxygen transport, relaxed state, tense state, globin fold, red blood cell
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 33454.87

Authors

Safo, M.K.,Meadows, J.,Ko, T.-P.,Nakagawa, A.,Zapol, W. (deposition date: 2013-11-05, release date: 2014-09-17, Last modification date: 2023-09-20)

• Primary citation: Nakagawa, A.,Lui, F.E.,Wassaf, D.,Yefidoff-Freedman, R.,Casalena, D.,Palmer, M.A.,Meadows, J.,Mozzarelli, A.,Ronda, L.,Abdulmalik, O.,Bloch, K.D.,Safo, M.K.,Zapol, W.M.; Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling.; Acs Chem.Biol., 9:2318-2325, 2014; PubMed: 25061917; DOI: 10.1021/cb500230b

Experimental method

X-RAY DIFFRACTION (1.9 Å)