4NI0
Quaternary R3 CO-liganded hemoglobin structure in complex with a thiol containing compound
Summary for 4NI0
Entry DOI | 10.2210/pdb4ni0/pdb |
Related | 4NI1 |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (8 entities in total) |
Functional Keywords | allosteric, tetramer, oxygen transport, relaxed state, tense state, globin fold, red blood cell |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 33831.92 |
Authors | Safo, M.K.,Meadows, J.,Ko, T.-P.,Nakagawa, A.,Zapol, W. (deposition date: 2013-11-05, release date: 2014-08-20, Last modification date: 2023-09-20) |
Primary citation | Nakagawa, A.,Lui, F.E.,Wassaf, D.,Yefidoff-Freedman, R.,Casalena, D.,Palmer, M.A.,Meadows, J.,Mozzarelli, A.,Ronda, L.,Abdulmalik, O.,Bloch, K.D.,Safo, M.K.,Zapol, W.M. Identification of a Small Molecule that Increases Hemoglobin Oxygen Affinity and Reduces SS Erythrocyte Sickling. Acs Chem.Biol., 9:2318-2325, 2014 Cited by PubMed: 25061917DOI: 10.1021/cb500230b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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