4NH9
Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
Summary for 4NH9
Entry DOI | 10.2210/pdb4nh9/pdb |
Related | 4NH7 4NH8 |
Descriptor | Endoplasmin, 2-fluoro-6-[(3S)-tetrahydrofuran-3-ylamino]-4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide (2 entities in total) |
Functional Keywords | a/b structure, chaperone, endoplasmic reticulum |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum lumen: P14625 |
Total number of polymer chains | 1 |
Total formula weight | 31485.28 |
Authors | Zuccola, H.J.,Ernst, J.T. (deposition date: 2013-11-04, release date: 2014-01-22, Last modification date: 2024-02-28) |
Primary citation | Ernst, J.T.,Liu, M.,Zuccola, H.,Neubert, T.,Beaumont, K.,Turnbull, A.,Kallel, A.,Vought, B.,Stamos, D. Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective inhibitors for treating neurodegenerative diseases. Bioorg.Med.Chem.Lett., 24:204-208, 2014 Cited by PubMed: 24332488DOI: 10.1016/j.bmcl.2013.11.036 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.77 Å) |
Structure validation
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