4N9K

crystal structure of beta-lactamse PenP_E166S in complex with cephaloridine

Summary for 4N9K

• Entry DOI: 10.2210/pdb4n9k/pdb
• Related: 4N92 4N9L
• Descriptor: Beta-lactamase, 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID (3 entities in total)
• Functional Keywords: hydrolase, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Bacillus licheniformis
• Cellular location: Cell membrane; Lipid-anchor (Probable): P00808
• Total number of polymer chains: 2
• Total formula weight: 60252.37

Authors

Pan, X.,Wong, W.,Zhao, Y. (deposition date: 2013-10-21, release date: 2014-09-10)

• Primary citation: Pan, X.,Wong, W.,He, Y.,Jiang, Y.,Zhao, Y.; Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation; Biochemistry, 53:5414-5423, 2014; PubMed: 25020031; DOI: 10.1021/bi401609h

Experimental method

X-RAY DIFFRACTION (1.93 Å)