4N90
Crystal structure of ternary complex of TRAIL, DR5, and Fab fragment from a DR5 agonist antibody
Summary for 4N90
Entry DOI | 10.2210/pdb4n90/pdb |
Descriptor | Tumor necrosis factor receptor superfamily member 10B, Tumor necrosis factor ligand superfamily member 10, Fab light chain, ... (5 entities in total) |
Functional Keywords | dr5, trail, agonist, antibody, cooperation, clustering, apoptosis-immune system complex, apoptosis/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: O14763 Membrane; Single-pass type II membrane protein (Potential): P50591 |
Total number of polymer chains | 12 |
Total formula weight | 242778.05 |
Authors | |
Primary citation | Graves, J.D.,Kordich, J.J.,Huang, T.H.,Piasecki, J.,Bush, T.L.,Sullivan, T.,Foltz, I.N.,Chang, W.,Douangpanya, H.,Dang, T.,O'Neill, J.W.,Mallari, R.,Zhao, X.,Branstetter, D.G.,Rossi, J.M.,Long, A.M.,Huang, X.,Holland, P.M. Apo2L/TRAIL and the Death Receptor 5 Agonist Antibody AMG 655 Cooperate to Promote Receptor Clustering and Antitumor Activity. Cancer Cell, 26:177-189, 2014 Cited by PubMed: 25043603DOI: 10.1016/j.ccr.2014.04.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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