4N1Z
Crystal Structure of Human Farnesyl Diphosphate Synthase in Complex with BPH-1222
Summary for 4N1Z
Entry DOI | 10.2210/pdb4n1z/pdb |
Related | 4GA3 |
Descriptor | Farnesyl pyrophosphate synthase, PHOSPHATE ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | alpha fold, synthase, ionization, dephosphorylation, cytosol, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 40676.85 |
Authors | Liu, Y.L.,Xia, Y.,Zhang, Y.,Verma, I.,Oldfield, E. (deposition date: 2013-10-04, release date: 2014-12-10, Last modification date: 2023-09-20) |
Primary citation | Xia, Y.,Liu, Y.L.,Xie, Y.,Zhu, W.,Guerra, F.,Shen, S.,Yeddula, N.,Fischer, W.,Low, W.,Zhou, X.,Zhang, Y.,Oldfield, E.,Verma, I.M. A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin. Sci Transl Med, 6:263ra161-263ra161, 2014 Cited by PubMed: 25411474DOI: 10.1126/scitranslmed.3010382 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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