4N12

Crystal structure of human E18D DJ-1 in complex with Cu

Summary for 4N12

• Entry DOI: 10.2210/pdb4n12/pdb
• Related: 4MNT 4N0M
• Descriptor: Protein DJ-1, COPPER (II) ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: alpha/beta structure, chaperone, oxidative stress protection, cytosol, nucleus, mitochondria, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Lipid-anchor: Q99497
• Total number of polymer chains: 1
• Total formula weight: 20060.64

Authors

Cendron, L.,Girotto, S.,Bisaglia, M.,Tessari, I.,Mammi, S.,Zanotti, G.,Bubacco, L. (deposition date: 2013-10-03, release date: 2014-03-05, Last modification date: 2014-11-12)

• Primary citation: Girotto, S.,Cendron, L.,Bisaglia, M.,Tessari, I.,Mammi, S.,Zanotti, G.,Bubacco, L.; DJ-1 Is a Copper Chaperone Acting on SOD1 Activation.; J.Biol.Chem., 289:10887-10899, 2014; PubMed: 24567322; DOI: 10.1074/jbc.M113.535112

Experimental method

X-RAY DIFFRACTION (1.478 Å)