4MRO

Human GKRP bound to AMG-5980 and S6P

Summary for 4MRO

• Entry DOI: 10.2210/pdb4mro/pdb
• Related: 4MQU
• Descriptor: Glucokinase regulatory protein, 2-(4-{4-[(6-aminopyridin-3-yl)sulfonyl]piperazin-1-yl}phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol, D-SORBITOL-6-PHOSPHATE, ... (7 entities in total)
• Functional Keywords: sis domains, regulatory protein, glucokinase, phospho-fructose, transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus (By similarity): Q14397
• Total number of polymer chains: 2
• Total formula weight: 145403.00

Authors

St Jean, D.J.,Ashton, K.S.,Bartberger, M.D.,Chen, J.,Chmait, S.,Cupples, R.,Galbreath, E.,Helmering, J.,Jordan, S.R.,Liu, L.,Kunz, K.,Michelsen, K.,Nishimura, N.,Pennington, L.D.,Poon, S.F.,Sivits, G.,Stec, M.M.,Tamayo, N.,Van, G.,Yang, K.,Norman, M.H.,Fotsch, C.,LLoyd, D.J.,Hale, C. (deposition date: 2013-09-17, release date: 2014-05-07, Last modification date: 2024-04-03)

• Primary citation: St Jean, D.J.,Ashton, K.S.,Bartberger, M.D.,Chen, J.,Chmait, S.,Cupples, R.,Galbreath, E.,Helmering, J.,Hong, F.T.,Jordan, S.R.,Liu, L.,Kunz, R.K.,Michelsen, K.,Nishimura, N.,Pennington, L.D.,Poon, S.F.,Reid, D.,Sivits, G.,Stec, M.M.,Tadesse, S.,Tamayo, N.,Van, G.,Yang, K.C.,Zhang, J.,Norman, M.H.,Fotsch, C.,Lloyd, D.J.,Hale, C.; Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.; J.Med.Chem., 57:325-338, 2014; PubMed: 24405213; DOI: 10.1021/jm4016747

Experimental method

X-RAY DIFFRACTION (2.2 Å)