4MRO
Human GKRP bound to AMG-5980 and S6P
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glucokinase regulatory protein | polymer | 636 | 70178.5 | 2 | UniProt (Q14397) Pfam (PF22645) Pfam (PF22198) Pfam (PF20741) | Homo sapiens (human) | Glucokinase regulator |
| 2 | C, Q (A, B) | 2-(4-{4-[(6-aminopyridin-3-yl)sulfonyl]piperazin-1-yl}phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol | non-polymer | 484.4 | 2 | Chemie (MG0) PubChem (73659150) | |||
| 3 | D, R (A, B) | D-SORBITOL-6-PHOSPHATE | non-polymer | 262.2 | 2 | Chemie (S6P) PubChem (618) PubChem (130418) PubChem (152306) PubChem (440969) PubChem (445703) PubChem (14620017) PubChem (21968234) PubChem (17754155) PubChem (53827506) PubChem (92209470) PubChem (92177220) PubChem (124335010) PubChem (163321747) PubChem (165361689) | |||
| 4 | AA, BA, CA, DA, E... (B, A) | IODIDE ION | non-polymer | 126.9 | 25 | Chemie (IOD) PubChem (30165) | |||
| 5 | P (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 6 | GA, HA, IA (B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | JA, KA (A, B) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 625 (UniProt: Q14397)
| PDB | External Database | Details |
|---|---|---|
| Met -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Glu -2 | - | expression tag |
| Val -1 | - | expression tag |
| Asp 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 140357.0 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 5046.0 | |
| All* | Total formula weight | 145403.0 |
