4LWE
Crystal Structure of the human Hsp90-alpha N-domain bound to the hsp90 inhibitor FJ2
Summary for 4LWE
Entry DOI | 10.2210/pdb4lwe/pdb |
Related | 4LWF 4LWG 4LWH 4LWI |
Descriptor | Heat shock protein HSP 90-alpha, N-[3-(5-chloro-2,4-dihydroxyphenyl)-4-(4-methoxyphenyl)-1,2-oxazol-5-yl]acetamide (3 entities in total) |
Functional Keywords | rossmann fold, atp binding, molecularchaperone, chaperone |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P07900 |
Total number of polymer chains | 1 |
Total formula weight | 23638.18 |
Authors | |
Primary citation | Chen, D.,Shen, A.,Li, J.,Shi, F.,Chen, W.,Ren, J.,Liu, H.,Xu, Y.,Wang, X.,Yang, X.,Sun, Y.,Yang, M.,He, J.,Wang, Y.,Zhang, L.,Huang, M.,Geng, M.,Xiong, B.,Shen, J. Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors. Eur.J.Med.Chem., 87:765-781, 2014 Cited by PubMed: 25313505DOI: 10.1016/j.ejmech.2014.09.065 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report