4LQG

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a phosphoramidate inhibitor CTT1056

Summary for 4LQG

• Entry DOI: 10.2210/pdb4lqg/pdb
• Related PRD ID: PRD_001140
• Descriptor: Glutamate carboxypeptidase 2, N-(4-fluorobenzoyl)-L-gamma-glutamyl-5-{[(S)-{[(1S)-1,3-dicarboxypropyl]amino}(hydroxy)phosphoryl]oxy}-L-norvaline, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: peptidase, hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type II membrane protein . Isoform PSMA': Cytoplasm : Q04609
• Total number of polymer chains: 1
• Total formula weight: 84164.10

Authors

Barinka, C.,Skultetyova, L. (deposition date: 2013-07-18, release date: 2014-12-31, Last modification date: 2020-07-29)

• Primary citation: Dannoon, S.,Ganguly, T.,Cahaya, H.,Geruntho, J.J.,Galliher, M.S.,Beyer, S.K.,Choy, C.J.,Hopkins, M.R.,Regan, M.,Blecha, J.E.,Skultetyova, L.,Drake, C.R.,Jivan, S.,Barinka, C.,Jones, E.F.,Berkman, C.E.,VanBrocklin, H.F.; Structure-Activity Relationship of (18)F-Labeled Phosphoramidate Peptidomimetic Prostate-Specific Membrane Antigen (PSMA)-Targeted Inhibitor Analogues for PET Imaging of Prostate Cancer.; J.Med.Chem., 59:5684-5694, 2016; PubMed: 27228467; DOI: 10.1021/acs.jmedchem.5b01850

Experimental method

X-RAY DIFFRACTION (1.77 Å)