4LDJ

Crystal Structure of a GDP-bound G12C Oncogenic Mutant of Human GTPase KRas

Summary for 4LDJ

Entry DOI	10.2210/pdb4ldj/pdb
Related	4NMM
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	small gtpase, gdp bound, oncogenic mutation, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
Total number of polymer chains	1
Total formula weight	19842.41
Authors	Hunter, J.C.,Gurbani, D.,Chen, Z.,Westover, K.D. (deposition date: 2013-06-24, release date: 2014-06-04, Last modification date: 2023-09-20)
Primary citation	Hunter, J.C.,Gurbani, D.,Ficarro, S.B.,Carrasco, M.A.,Lim, S.M.,Choi, H.G.,Xie, T.,Marto, J.A.,Chen, Z.,Gray, N.S.,Westover, K.D. In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111:8895-8900, 2014 Cited by PubMed: 24889603 DOI: 10.1073/pnas.1404639111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation