4L1S
Covalent modification of transthyretin K15 by yielding the fluorescent conjugate (E)-3-(dimethylamino)-5-(4-hydroxy-3,5-dimethylstyryl)benzamide
Summary for 4L1S
| Entry DOI | 10.2210/pdb4l1s/pdb |
| Related | 4FI6 4L1T |
| Descriptor | Transthyretin, S-(4-fluorophenyl) 3-(dimethylamino)-5-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]benzenecarbothioate (3 entities in total) |
| Functional Keywords | hormone transport protein, thyroxine, retinol, transport protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted: P02766 |
| Total number of polymer chains | 2 |
| Total formula weight | 28397.77 |
| Authors | Connelly, S.,Wilson, I.A. (deposition date: 2013-06-03, release date: 2013-10-02, Last modification date: 2023-09-20) |
| Primary citation | Baranczak, A.,Connelly, S.,Liu, Y.,Choi, S.,Grimster, N.P.,Powers, E.T.,Wilson, I.A.,Kelly, J.W. Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn. Biopolymers, 101:484-495, 2014 Cited by PubMed: 24105107DOI: 10.1002/bip.22407 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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