4L19

Matrix metalloproteinase-13 complexed with selective inhibitor compound Q1

Summary for 4L19

Entry DOI	10.2210/pdb4l19/pdb
Descriptor	Collagenase 3, ZINC ION, CALCIUM ION, ... (7 entities in total)
Functional Keywords	metalloprotease, hydrolase, mmp-13, collagenase, exosite inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P45452
Total number of polymer chains	2
Total formula weight	40281.63
Authors	Minond, D.,Spicer, T.P.,Jiang, J.,Taylor, A.B.,Hart, P.J.,Roush, W.R.,Fields, G.B.,Hodder, P.S. (deposition date: 2013-06-02, release date: 2014-12-10, Last modification date: 2023-09-20)
Primary citation	Spicer, T.P.,Jiang, J.,Taylor, A.B.,Choi, J.Y.,Hart, P.J.,Roush, W.R.,Fields, G.B.,Hodder, P.S.,Minond, D. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro. J.Med.Chem., 57:9598-9611, 2014 Cited by PubMed: 25330343 DOI: 10.1021/jm501284e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation