Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS172 |
| A | ASP174 |
| A | HIS187 |
| A | HIS200 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS222 |
| A | HIS226 |
| A | HIS232 |
| A | FMT306 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 303 |
| Chain | Residue |
| A | SER250 |
| A | HIS251 |
| A | GOL309 |
| A | HIS131 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 304 |
| Chain | Residue |
| A | ASP179 |
| A | GLY180 |
| A | SER182 |
| A | LEU184 |
| A | ASP202 |
| A | GLU205 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 305 |
| Chain | Residue |
| A | ASP162 |
| A | ASN194 |
| A | GLY196 |
| A | ASP198 |
| A | HOH407 |
| A | HOH458 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 306 |
| Chain | Residue |
| A | HIS222 |
| A | GLU223 |
| A | HIS226 |
| A | HIS232 |
| A | ZN302 |
| A | 1UA308 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1UA A 307 |
| Chain | Residue |
| A | LEU218 |
| A | HIS222 |
| A | LEU239 |
| A | PHE241 |
| A | ILE243 |
| A | THR245 |
| A | THR247 |
| A | PHE252 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 1UA A 308 |
| Chain | Residue |
| A | TYR176 |
| A | ALA188 |
| A | PHE189 |
| A | HIS226 |
| A | FMT306 |
| A | HOH494 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 309 |
| Chain | Residue |
| A | HIS131 |
| A | GLU135 |
| A | ARG155 |
| A | SER250 |
| A | ZN303 |
| B | PRO127 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | HIS172 |
| B | ASP174 |
| B | HIS187 |
| B | HIS200 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS222 |
| B | HIS226 |
| B | HIS232 |
| B | FMT305 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| B | ASP162 |
| B | ASN194 |
| B | GLY196 |
| B | ASP198 |
| B | HOH489 |
| B | HOH505 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| B | ASP179 |
| B | GLY180 |
| B | SER182 |
| B | LEU184 |
| B | ASP202 |
| B | GLU205 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT B 305 |
| Chain | Residue |
| B | HIS222 |
| B | GLU223 |
| B | HIS226 |
| B | HIS232 |
| B | ZN302 |
| B | HOH458 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FMT B 306 |
| Chain | Residue |
| A | THR130 |
| A | HIS131 |
| B | THR130 |
| B | HIS131 |
| B | HOH408 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 307 |
| Chain | Residue |
| B | LYS234 |
| B | GLN263 |
| B | HOH442 |
| B | HOH464 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE FMT B 308 |
| Chain | Residue |
| B | LYS115 |
| B | MET116 |
| B | ASN117 |
| B | HOH460 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1UA B 309 |
| Chain | Residue |
| B | HIS222 |
| B | GLY237 |
| B | LEU239 |
| B | PHE241 |
| B | ILE243 |
| B | TYR244 |
| B | THR245 |
| B | PHE252 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 310 |
| Chain | Residue |
| B | HOH493 |
| B | HOH555 |
| B | TYR176 |
| B | ALA188 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 311 |
| Chain | Residue |
| B | ARG155 |
| B | LEU156 |
| B | HIS157 |
| B | ASP158 |
| B | HOH413 |
| B | HOH498 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
| Chain | Residue | Details |
| A | VAL219-LEU228 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU223 | |
| B | GLU223 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
| Chain | Residue | Details |
| A | ASP128 | |
| A | ASP202 | |
| A | ASP203 | |
| A | GLU205 | |
| B | ASP128 | |
| B | ASP162 | |
| B | ASP179 | |
| B | GLY180 | |
| B | SER182 | |
| B | LEU184 | |
| B | ASN194 | |
| A | ASP162 | |
| B | GLY196 | |
| B | ASP198 | |
| B | ASP202 | |
| B | ASP203 | |
| B | GLU205 | |
| A | ASP179 | |
| A | GLY180 | |
| A | SER182 | |
| A | LEU184 | |
| A | ASN194 | |
| A | GLY196 | |
| A | ASP198 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
| Chain | Residue | Details |
| A | HIS172 | |
| B | ASP174 | |
| B | HIS187 | |
| B | HIS200 | |
| B | HIS222 | |
| B | HIS226 | |
| B | HIS232 | |
| B | MET240 | |
| A | ASP174 | |
| A | HIS187 | |
| A | HIS200 | |
| A | HIS222 | |
| A | HIS226 | |
| A | HIS232 | |
| A | MET240 | |
| B | HIS172 | |
| Chain | Residue | Details |
| A | ASN117 | |
| B | ASN117 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN152 | |
| B | ASN152 | |
