4KYA
Crystal structure of non-classical TS inhibitor 3 in complex with Toxoplasma gondii TS-DHFR
Summary for 4KYA
Entry DOI | 10.2210/pdb4kya/pdb |
Related | 4EIL 4KY4 |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-Amino-5-(1-naphthylsulfanyl)-3,9-dihydro-4H-pyrimido[4,5-b]indol-4-one, ... (5 entities in total) |
Functional Keywords | synthase, bifunctional, chimera protein, oxidoreductase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Toxoplasma gondii More |
Total number of polymer chains | 8 |
Total formula weight | 528541.82 |
Authors | Sharma, H.,Anderson, K.S. (deposition date: 2013-05-28, release date: 2014-08-06, Last modification date: 2023-09-20) |
Primary citation | Zaware, N.,Sharma, H.,Yang, J.,Devambatla, R.K.,Queener, S.F.,Anderson, K.S.,Gangjee, A. Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections. ACS Med Chem Lett, 4:1148-1151, 2013 Cited by PubMed: 24470841DOI: 10.1021/ml400208v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.263 Å) |
Structure validation
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