4KU1
Role of the hinge and C-gamma-2/C-gamma-3 interface in immunoglobin G1 Fc domain motions: implications for Fc engineering
Summary for 4KU1
Entry DOI | 10.2210/pdb4ku1/pdb |
Descriptor | Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | human fc fragment, immune response, immune system |
Biological source | HOMO SAPIENS (human) |
Cellular location | Secreted: P01857 |
Total number of polymer chains | 2 |
Total formula weight | 50876.70 |
Authors | Frank, M.,Walker, R.,Lanzilotta, W.N.,Prestegard, J.H.,Barb, A.W. (deposition date: 2013-05-21, release date: 2014-02-19, Last modification date: 2020-07-29) |
Primary citation | Frank, M.,Walker, R.C.,Lanzilotta, W.N.,Prestegard, J.H.,Barb, A.W. Immunoglobulin g1 fc domain motions: implications for fc engineering. J.Mol.Biol., 426:1799-1811, 2014 Cited by PubMed: 24522230DOI: 10.1016/j.jmb.2014.01.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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