4KTU

Bovine trypsin in complex with microviridin J at pH 6.5

Summary for 4KTU

• Entry DOI: 10.2210/pdb4ktu/pdb
• Related: 3MYW 4KTS
• Related PRD ID: PRD_001086
• Descriptor: Cationic trypsin, microviridin j, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: serine protease, hydrolase, natural product inhibitor, trypsin, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Microcystis aeruginosa MRC; More
• Cellular location: Secreted, extracellular space: P00760
• Total number of polymer chains: 2
• Total formula weight: 25089.23

Authors

Quitterer, F.,Groll, M.,Hertweck, C.,Dittmann, E. (deposition date: 2013-05-21, release date: 2014-04-02, Last modification date: 2023-09-20)

• Primary citation: Weiz, A.R.,Ishida, K.,Quitterer, F.,Meyer, S.,Kehr, J.C.,Muller, K.M.,Groll, M.,Hertweck, C.,Dittmann, E.; Harnessing the evolvability of tricyclic microviridins to dissect protease-inhibitor interactions.; Angew.Chem.Int.Ed.Engl., 53:3735-3738, 2014; PubMed: 24591244; DOI: 10.1002/anie.201309721

Experimental method

X-RAY DIFFRACTION (1.35 Å)